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Pyrazolines and pyrimidines based on (E)-1-(4-pentyloxyphenyl)-3-arylprop-2-en-1-ones. Synthesis, docking study and luminescent properties

Year: 2024

Type: article

Abstract: (E)-1-(4-Pentyloxyphenyl)-3-(aryl)prop-2-en-1-ones were obtained by condensation of 1-(4-pentyloxyphenyl)ethanone with aromatic aldehydes in an aqueous ethanol solution in the presence of NaOH. The corresponding pyrazoline derivatives were prepared by cyclization of substituted chalcones with phenylhydrazine in an acidic medium, while 2,4,6-triaryl-substituted pyrimidines were produced in the case of benzamidine hydrochloride in the KOH–ethanol. It was found that all synthesized pyrazoline derivatives exhibit pronounced luminescent properties. A docking study of the compounds was carried out against four types of receptors.

Source: Журнал Общей Химии

DOI: 10.31857/s0044460x24050048

Authors: A. U. Isakhanyan, Z. A. Ovasyan, G. S. Grigoryan, R. P. Mkhitaryan, L. S. Gabrielyan, G. A. Panosyan, M. Yu. Dangyan, A. S. Sargsyan, A. A. Hambardzumyan, A. A. Harutyunyan

Institutions: A. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Yerevan State University, Scientific and Production Center “Armbiotechnology” NAS RA

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4404337414

FWCI:

Cites: 23

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Related to: 10