Work

NINJ1: Bridging lytic cell death and inflammation therapy

Year: 2024

Type: article

Abstract: NINJ1, a critical transmembrane protein in inflammation, governs diverse biological processes. Recent breakthroughs revealed NINJ1's structural basis for plasma membrane rupture, which is directly linked to lytic cell death. This discussion explores NINJ1's functions, focusing on its pivotal role in lytic cell death regulation and the latest advancements in targeted therapeutic interventions.

Source: Cell Death and Disease

DOI: 10.1038/s41419-024-07203-6

Authors: Jinze Shen, Ruixiu Chen, Shiwei Duan

Institution: Hangzhou City University

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,790