Ion exchange in the system: DOWEX 50 sulfocationite, aqueous solution of Cu(NO3)2 and pyridine-2-carboxylic acid
Year: 2024
Type: article
Abstract: Coordination compounds of inorganic cations with biologically active substances are of considerable interest due to the fact that they have more pronounced pharmacological properties than free ligands. Immobilization of coordination compounds in ion exchangers facilitates the implementation of specified pharmacokinetics, provides significant prospects in matters of conservation and storage of bioactive substances, and allows for targeted delivery of the active component to the site of the disease. Previously, the ligand sorption of pyridine-3-carboxylic acid from its aqueous solution onto the Dowex-50 cation exchanger in Cu(II) form was studied. The goal of this work is to show the possibility of immobilizing pyridine-2-carboxylic acid and copper(II) in the Dowex-50 sulfonic cation exchanger on a styrene-divinylbenzene matrix, to study the equilibrium distribution of components between Dowex-50 sulfonic cation exchange resin and an aqueous solution containing pyridine-2-carboxylic acid and copper(II) cations. Show the possibility of preliminary calculation of the equilibrium composition of an aqueous solution of a mixture of pyridine-2-carboxylic acid and salt of copper to obtain the counterionic composition of the Dowex-50 sulfonic cation exchanger, which is of interest for optimizing technological processes of encapsulated preparations based on pyridinecarboxylic acids and inorganic cations production. The equilibrium distribution of components between aqueous solutions of pyridine-2-carboxylic acid, copper nitrate and Dowex-50 sulfonic cation exchanger was studied by the dynamic method at a temperature of 298 K. The working pH range of equilibrium solutions was selected in the range 2.0 – 2.5, based on the content of components in the solution and their ability participate in the cation exchange reaction. Based on the results of the study, we came to the conclusion that in multicomponent heterophase systems consisting of Dowex-50 sulfonic cation exchanger and aqueous solutions of pyridine-2-carboxylic acid and copper nitrate, equilibrium reactions of complexation and ion exchange occur. It has been shown that using the selectivity coefficients of binary ion exchanges and the formation constants of [H2L]+, [CuL]+ complexes, it is possible to pre-calculate the equilibrium ionic compositions of the solution and the Dowex-50 sulfonic cation exchanger. Probably, Dowex-50 sulfonic cation exchanger can be proposed as a container of the drugs based on pyridine-2-carboxylic acid and copper(II) cations.
Authors: Heinrich N. Altshuler, Vladimir N. Nekrasov, Olga H. Altshuler
Language: English
Subfield: Polymers and Plastics
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4404379434