Figure 2 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers
Year: 2024
Type: other
Abstract: Model simulations of treatment by pure radioconjugates (coefficient of drug impurity η = 0) for the basic set of parameters with the dose Acur leading to minimal number of viable cancer cells Nm = 0.01, which is considered as the curative threshold. A, Dynamics of active antibodies and their fragments in plasma. B, Dynamics of cancer cells. C, Dependence of minimal single curative dose, Acur, on relative significance of self-damage, ks. Star marks the case with basic value of ks = 0.3. See Supplementary Section S.2.1.6 for analytical estimation of Acur. D, Dynamics of occupied receptors on viable cancer cells. The density of radionuclides on them decreases due to the decay of nuclides, rate of which is λ, and due the to the redistribution of nuclides among the newborn cells, characterized by cell proliferation rate ρ. E, Dynamics of occupied receptors on damaged cancer cells. After a transient period, the density of radionuclides on them decreases only due to the decay of nuclides.
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4404384852