Figure 5 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers
Year: 2024
Type: other
Abstract: Survival curves for the test set of virtual mice, grouped by relative significance of self-damage, ks: (A) low ks; (B) intermediate ks; and (C) high ks. Personalized schedules based on cancer-binding capacity, γN0, yield robust treatment optimization via initial saturation of cancer-binding capacity with the first dose, enabling redistribution of further injected small doses toward still viable cells that continue expressing specific receptors. Coefficient of drug impurity, η, corresponds to the labeling ratio of 1.85 kBq/μg.
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4404384853