Figure 3 from Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers
Year: 2024
Type: other
Abstract: Dependence of minimal single curative dose, Acur, on the coefficient of drug impurity, η, i.e., the ratio of unlabeled antibodies to radioconjugates. A, Moderate variation in η. Under significant self-damage, saturation of specific receptors leads to redirection of radioconjugates and deposited doses toward still viable cells, which continue generating specific receptors. This effect yields the decrease in Acur with an increase in η. B, Extended variation of η. The curative treatment becomes lethally toxic shortly after the amount of injected antibodies, (η + 1)Acur, exceeds the total amount of specific receptors expressed on cancer cells during treatment.
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4404385329