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No detectable loss of myonuclei from human muscle fibers after 6 wk of immobilization following an Achilles tendon rupture

Year: 2024
Type: article
Abstract: The impact of prolonged immobilization on muscle fiber characteristics is difficult to study in humans and therefore remains poorly understood. We analyzed cross-sections and single fibers from gastrocnemius before and after 6 wk of immobilization due to an Achilles tendon rupture. Our data suggest that myonuclei are not lost in response to such stimuli, thus lending support to the hypothesis of myonuclear permanency in human muscle.
DOI: 10.1152/ajpcell.00692.2024
Authors: Oscar Horwath, Kristoffer Toldnes Cumming, Einar Eftestøl, Björn Ekblom, Paul Ackermann, Truls Raastad, Kristian Gundersen, Niklas Psilander
Institutions: Swedish School of Sport and Health Sciences, Østfold University of Applied Sciences, Norwegian School of Sport Sciences, University of Oslo, Karolinska University Hospital, Karolinska Institutet
Language: English
Open Access status: hybrid
Estimated APC paid: $3,526
OpenAlex ID: W4404393214
FWCI: 0.707
Cites: 26
Cited by: 6
Related to: 10