Diethyl Phosphate‐Catalyzed One‐Pot Synthesis of 2,3‐Dihydroquinolin‐4(1 H )‐ones from 2‐Aminoacetophenones and Benzaldehydes
Year: 2024
Type: article
Abstract: A diethyl phosphate (DEP)‐catalyzed one‐pot synthesis of 2,3‐dihydroquinolin‐4(1 H )‐ones in DMF was achieved. Control experiments led to a plausible mechanism involving an intermolecular aldol condensation of 2‐aminoacetophenone and aldehyde, followed by a hydrogen bond‐driven cyclization. In this process, a series of 2,3‐dihydroquinolin‐4(1 H )‐ones were obtained in good yields (48–84%). This strategy features transition metal‐free and short reaction times.
Source: ChemistrySelect
Authors: Lanfeng He, Enhua Wang, Shuang Zheng, Yingguo Ban, Kaiping Hou, Lishou Yang, Xiaosheng Yang
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Awards: G2860682037, G4036636633
OpenAlex ID: W4404394173