Work

Biochemical Signal‐Induced Supramolecular Hydrogelation for Structured Free‐Standing Soft Material Formation

Year: 2024

Type: article

Abstract: Cells coordinate their activity and regulate biological processes in response to chemical signals. Mimicking natural processes, control over the formation of artificial supramolecular materials is of high interest for their application in biology and medicine. Supramolecular material that can form in response to chemical signals is important for the development of autonomously responsive materials. Herein, a supramolecular hydrogel system is reported enabling in situ generation of hydrogelators in response to a specific chemical signal. Using self‐immolative chemistry, spatial control over the formation of supramolecular hydrogel material and structured free‐standing hydrogel objects via providing H2O2 locally is demonstrated. In addition, a hybrid system is developed enabling in situ generation of the H2O2 by the action of an enzyme and glucose, providing an extra handle for the development of an intelligent soft material. This generic design should enable the use of various (chemical)stimuli that can be obtained via coupling different stimuli and various chemical and/or biological markers and appears a versatile approach for the design of smart artificial soft materials that can find application in theranostic purposes.

Source: Macromolecular Bioscience

DOI: 10.1002/mabi.202400419

Authors: Dineshkumar Bharathidasan, Akshay Sunil Salvi, Suryasarathi Bose, Chandan Maity

Institutions: Vellore Institute of Technology University, Indian Institute of Science Bangalore

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: bronze

Funder: VIT University

Award: G8894745562