Discovery of undescribed anthracycline-derived polyketides with cytotoxicity from endophytic Streptomyces chartreusis M7
Year: 2024
Type: article
Abstract: Endophytic actinomycetes exhibit considerable potential for the production of biologically active metabolites due to their coevolution with plant hosts. In this study, an endophytic Streptomyces chartreusis M7 was isolated from Houttuynia cordata Thunb. Bioactivity-guided investigation of the metabolites produced by this strain led to the identification of thirteen anthracycline-derived polyketides , including five unreported anthraquinones designated streptoquinones A-E ( 1 – 5 ) and two undescribed angular polyketides named chartins A and B ( 6 – 7 ) along with six knowns. Their structures were elucidated through comprehensive spectroscopic analysis and ECD calculations. Notably, chartins A ( 6 ) and B ( 7 ) feature angular tetracyclic and pentacyclic skeletons, respectively, which have undergone several oxidative rearrangements. Moreover, streptoquinone A ( 1 ) exhibited moderate cytotoxicity against A549 cells, with an IC 50 value of 4.8 μM.
Source: Phytochemistry
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,150
OpenAlex ID: W4404402941