Work

Selective targeting of phosphodiesterases to develop potent antiparasitic drugs

Year: 2024

Type: article

Abstract: Regulation of intracellular cyclic nucleotides to avoid homeostatic imbalances is achieved through catabolic activity of phosphodiesterases (PDEs). Recently, Ajiboye et al. reported validation of Cryptosporidium PDE1 (CpPDE1) as a viable drug target and identified optimized pyrazolopyrimidines with selective activity against CpPDE1 over human PDEs and with potent anticryptosporidial efficacy.

Source: Trends in Parasitology

DOI: 10.1016/j.pt.2024.11.001

Authors: Shahbaz M. Khan, Md Mukthar Mia, William H. Witola

Institutions: Johns Hopkins University, University of Illinois Urbana-Champaign

Language: English

Topic: Phosphodiesterase function and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030