Work

Role of myofiber-specific FoxP1 in pancreatic cancer-induced muscle wasting

Year: 2024

Type: article

Abstract: Here we identify myofiber-derived FoxP1 as a negative regulator of skeletal muscle with sex-specific effects in cancer. Under cancer-free conditions, FoxP1 knockout increased myofiber size in male and female mice. However, in response to pancreatic cancer, FoxP1 myofiber-specific deletion attenuated muscle wasting and weakness in males but not females. This highlights the need to consider sexual dimorphism in cancer-induced muscle pathologies and provides evidence suggesting that targeting FoxP1 could help mitigate these effects in males.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00701.2024

Authors: Martin M. Schonk, Jeremy B. Ducharme, Daria Neyroud, Rachel L. Nosacka, Haley O. Tucker, Sarah M. Judge, Andrew R. Judge

Institutions: University of Florida Health, University of Florida, The University of Texas at Austin

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Cancer Prevention and Research Institute of Texas, National Institutes of Health, National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G3664986108, G4343941881, G4897168572, G541968693, FoxO signaling and skeletal muscle atrophy, Contribution of the BRIGHT transcription factor to autoimmune Diffuse Large B-cell Lymphoma, MAR Mediated Control of The IgH Enhancer, The University of Texas MD Anderson Cancer Center Science Park Next-Generation Sequencing Facility, University of Florida Health Cancer Center Support Grant, The Complement System and Cancer Cachexia

OpenAlex ID: W4404417800

FWCI: 0.577

Cites: 30

Cited by: 5

Related to: 10