Parameningeal Rhabdomyosarcoma: Results of the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 Study
Year: 2024
Type: article
Abstract: BACKGROUND: Parameningeal (PM) site is an unfavorable characteristic in rhabdomyosarcoma (RMS). We described the treatment and outcome for patients with PM RMS and investigated the prognostic value of risk factors. We scored PM site by originating site and by highest risk extension. METHODS: Patients with PM RMS were treated within the European pediatric Soft tissue sarcoma Study Group (EpSSG) RMS 2005 study with risk-adapted, multi-modal treatment. RESULTS: Three-hundred-eighty-one patients with PM RMS were included. Radiotherapy was administered in 359 patients (77 with surgery). After a median follow-up of 75 months, 5-year event-free survival was 60% (95% confidence interval (CI) 55%-65%), 5-year overall survival was 65% (95% CI 60%-70%). CONCLUSIONS: The outcome for patients with PM RMS has not improved in comparison to previous historical studies, despite the more rigorous application of radiotherapy (94% of patients). Signs of meningeal involvement, PM site, and age at diagnosis remained prognostic risk factors. TRIAL REGISTRATION: EudraCT number 2005-000217-35.
Source: Head & Neck
DOI: 10.1002/hed.27994
Authors: Reineke A. Schoot, Pieter Taselaar, Giovanni Scarzello, Frederic Kolb, Beatrice Coppadoro, Simone ter Horst, Henry Mandeville, Andrea Ferrari, Raquel Hladun, Sylvie Helfre, Sima Ferman, Anna Kelsey, Marinka L. F. Hol, Christine Devalck, Myriam Ben‐Arush, Daniel Orbach, Julia Chisholm, Meriel Jenney, Veronique Minard‐Colin, Gianni Bisogno, Johannes H. M. Merks
Institutions: Princess Máxima Center, Istituto Oncologico Veneto, University of California San Diego, University of Padua, University Medical Center Utrecht, Royal Marsden NHS Foundation Trust, Institute of Cancer Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Universitat Autònoma de Barcelona, Vall d'Hebron Hospital Universitari, Institut Curie, Instituto Nacional de Câncer - INCA, Royal Manchester Children's Hospital, Université Libre de Bruxelles, Queen Fabiola Children's University Hospital, Rambam Health Care Campus, Université Paris Sciences et Lettres, Royal Marsden Hospital, Inserm, Université Paris-Saclay, Institut Gustave Roussy, Utrecht University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,760
OpenAlex ID: W4404417808