Work

Efficacy of Daratumumab‐Based Regimens for Extramedullary Pulmonary Plasmacytoma: A Case Report

Year: 2024

Type: article

Abstract: INTRODUCTION: Multiple myeloma (MM) with pulmonary extramedullary disease is rare and usually associated with poor prognosis, and no data on daratumumab-based regimens have been reported yet. CASE PRESENTATION: Here, a 64-year-old man with pulmonary plasmacytoma received daratumumab-based regimens and has achieved a very good partial response with lung mass disappearance and overall survival of 16 months. He did not receive autologous stem cell transplantation because of several comorbidities, such as severe drug-induced neuropathy and JAK2-mutated myeloproliferative neoplasm with marked splenomegaly. CONCLUSIONS: We showed the efficacy of daratumumab in combination with targeted therapies for the treatment of pulmonary MM.

Source: Cancer Reports

DOI: 10.1002/cnr2.2149

Authors: Danilo De Novellis, Pio Zeppa, Elisabetta Maffei, Valentina Giudice, Carmine Selleri, Bianca Serio

Institutions: University of Salerno, AOU San Giovanni di Dio e Ruggi d'Aragona

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,970