Work

Unveiling the Significance of the Androgen Receptor Gene in Disorders of Sex Development

Year: 2024

Type: article

Abstract: Disorders of sex development (DSD) encompass a range of congenital conditions where the development of chromosomal, gonadal or anatomical sex is atypical. There are many genes associated with DSD, and one of them is the androgen receptor ( AR ) gene, which plays a pivotal role in normal sex development. Studies reported numerous genetic variations in the AR gene that lead to 46, XY DSD, including androgen insensitivity syndrome and hypospadias. Identifying and understanding the genetic causes of DSD will aid the healthcare providers design a tailored-made management for DSD patients and optimise patients’ quality of life. This narrative review will explore the significance of the AR gene in DSD while discussing DSD in general.

Source: Advances in Human Biology

DOI: 10.4103/aihb.aihb_137_24

Authors: Ziske Maritska, M Irsan Saleh, Fachmi Idris, Zen Hafy, Didit Pramudhito, Kemas Yusuf Effendi

Institution: Sriwijaya University

Language: English

Topic: Sexual Differentiation and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404436323

FWCI: 0.118

Cites: 31

Cited by: 1

Related to: 10