Year: 2024
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Aim: To demonstrate the genetic variant of CYP11B2 Gen rs1799998 and rs4539 and their ef f ect on systolic and diastolic blood pressure in Iraqi patient with essential hypertension in Aldiwania province. PATIENTS AND METHODS: Materials and Methods: This is an observational cross sectional descriptive single centre study for hypertensive patients at Al-Diwaniyah province, Iraq which is diagnosed according to 2020 ISH. All candidate patients were diagnosed and recruited by specialist caregiving physician/ cardiologist. There was a total of 90 participants, 37 males and 53 women. Aldosterone and renine levels in the plasma were determined from blood samples given voluntarily by patients undergoing genetic testing. RESULTS: Results: Regarding rs4539 the most frequent allele was T (112, 62%) while the most frequent genotype was TC (54, 60%). Regarding rs1799998 the most frequent allele was G (97, 54%) while the most frequent genotype was AG (49, 54%). CONCLUSION: Conclusions: There was no signif i cant relationship between rs1799998 (A344>G) and rs4539 (T2718C) with systolic and diastolic blood pressure in Iraqi patient with essential hypertension.
Source: Wiadomości Lekarskie
DOI: 10.36740/wlek/191330
Authors: Israa Mohammed Mahdy, Hussein A Saheb, Ahmed M Sultan, Bassim I Mohammad, Asma A Swadi, Sinaa Abdul Amir Kadhim
Institution: University of Al-Qadisiyah
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4404460930