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Features of the clinical course of arterial hypertension in patients with vitamin D deficiency

Year: 2024
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Aim: To determine the peculiarities of the daily prof i le of blood pressure in patients with arterial hypertension (AH) and vitamin D def i ciency and insuf f i ciency, to evaluate the parameters of the lipid prof i le and quality of life in these patients. PATIENTS AND METHODS: Materials and Methods: A total number of 97 patients with uncomplicated AH stage 1 and 2 were divided into 3 groups depending on the level of vitamin D in the blood serum. All patients underwent office blood pressure (BP) measurement and daily ambulatory BP monitoring for 24 hours, biochemical blood test with the determination of indicators of lipid metabolism, questionnaires for quality of life indicators. Statistical processing of the study results was carried out using "IBM SPSS Statistics 22". RESULTS: Results: "Non-dippers" are most often identif i ed in groups 1 and 2. Their prevalence is 1.8 times higher than in group 3 (p <0.05). The frequency of "night-peack-ers" in group 1 is 1.7 times higher than in group 2 and 2.6 times higher than in group 3 (p < 0.05). Patients with AH and vitamin D def i ciency have severe lipid metabolism disorders (p < 0.05). The correlation analysis shows a direct relationship of average strength between them and average daily systolic and diastolic BP indicators (р<0.05). CONCLUSION: Conclusions: Patients with AH and vitamin D def i ciency has an increase in cardiovascular risk, which is manifested by increase in pressure load indicators, frequency of detection of "night-peakers" and lipid metabolism disorders which is worsens of vascular accidents prognosis.
DOI: 10.36740/wlek/191876
Authors: Alina Tarasiuk, Vitalii Kondratiuk, Oleg Anatoliiovych Bychkov, Tetiana Ostashevska
Language: English
Field: Medicine
Open Access status: bronze
OpenAlex ID: W4404460990
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