Year: 2024
Type: review
Abstract: Micronutrient (MN) status alterations (both depletion and deficiency) are associated with several complications and worse outcomes in critically ill patients. On the other side of the spectrum, improving MN status has been shown to be a potential co‐adjuvant therapy. This review aims to collect existing data to better guide research in the critical care setting. This narrative review was conducted by the European Society of Intensive Care Medicine Feeding, Rehabilitation, Endocrinology, and Metabolism MN group. The primary objective was to identify studies focusing on individual MNs in critically ill patients, selecting the MNs that appear to be most relevant and most frequently investigated in the last decade: A, B1, B2, B3, B6, folate, C, D, E, copper, iron, selenium, zinc, and carnitine. Given the limited number of interventional studies for most MNs, observational studies were included. For each selected MN, the review summarizes the main form and functions, special needs and risk factors, optimal treatment strategies, pharmacological dosing, and clinical implications all specific to critically ill patients. A rigorous rebalancing of research strategies and priorities is needed to improve clinical practice. An important finding is that high‐dose monotherapy of MNs is not recommended. Basal daily needs must be provided, with higher doses in diseases with known higher needs, and identified deficiencies treated. Finally, the review provides a list of ongoing trials on MNs in critically ill patients and identifies a priority list of future research topics.
DOI: 10.1002/jpen.2700
Authors: Angelique M.E. de Man, Christian Stoppe, Kristine W.A.C. Koekkoek, George Briassoulis, Lilanthi S.D.P. Subasinghe, Cristian Cobilinschi, Adam M. Deane, William Manzanares, Ioana Grințescu, Liliana Mirea, Ashraf Roshdy, Antonella Cotoia, Danielle E. Bear, Sabrina Boraso, Vincent Fraipont, Kenneth B. Christopher, Michael P. Casaer, Jan Gunst, Olivier Pantet, Muhammed Elhadi, Giuliano Bolondi, Xavier Forceville, Matthias W.A. Angstwurm, Mohan Gurjar, Rodrigo Biondi, Arthur R.H. van Zanten, Mette M. Berger, ESICM/FREM MN group
Institutions: Amsterdam Cardiovascular Sciences, Amsterdam UMC Location Vrije Universiteit Amsterdam, Universitätsklinikum Würzburg, Martini Ziekenhuis, University of Crete, General Sir John Kotelawala Defence University, Carol Davila University of Medicine and Pharmacy, Clinical Emergency Hospital Bucharest, The University of Melbourne, Hospital de Clínicas, Alexandria University, University of Foggia, St Thomas' Hospital, King's College London, Guy's and St Thomas' NHS Foundation Trust, Ospedale dell' Angelo, Centre hospitalier régional de la Citadelle, Brigham and Women's Hospital, Universitair Ziekenhuis Leuven, KU Leuven, Centre Hospitalier Universitaire Vaudois, University of Tripoli, Ospedale “M. Bufalini” di Cesena, Inserm, CIC Rennes, Centre Hospitalier Universitaire de Rennes, Université de Rennes, LMU Klinikum, Ludwig-Maximilians-Universität München, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Ziekenhuis Gelderse Vallei, Wageningen University & Research, University of Lausanne
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,800
OpenAlex ID: W4404462786