Year: 2024
Type: article
Abstract: The article explores the mechanisms by which the gut microbiome influences human aging and associated diseases. The authors examine age-related changes in the composition of the microbiota and their effects on inflammation, immune response, and intestinal barrier permeability. Special attention is given to the pathogenic interactions between the gut microbiota and the development of cardiovascular, metabolic, and neurodegenerative diseases. The role of microbiome imbalance, known as dysbiosis, is highlighted as one of the key mechanisms accelerating the aging process. The review provides a comprehensive analysis of recent studies that demonstrate the impact of microbial metabolites on various body systems through the «gut-brain,» «gut-cardiovascular,» and «gut-endocrine» axes.
Source: Problems of Geroscience
Institution: Pirogov Russian National Research Medical University
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4404483354