Work

Manganese(I)‐Catalyzed Access to Enantioenriched Chiral Aziridine Phosphines

Year: 2024

Type: article

Abstract: Herein, we present the first catalytic asymmetric nucleophilic addition of diarylphosphines to 2 H ‐azirines, facilitated by a chiral Mn(I) complex. This method not only provides access to novel class of derivatives of the aziridine core – a structural motif recognized for its antitumor and antibacterial properties – but also introduces a phosphine moiety alongside the generation of an NH moiety within a strained three‐membered ring. The discovery of this new Mn(I) complex that both enables the reaction and induces stereoselectivity is pivotal, as it underscores the significant potential of this earth‐abundant metal in advancing asymmetric catalysis.

Source: Angewandte Chemie

DOI: 10.1002/ange.202415623

Authors: Chuang Ni, Tizian‐Frank Ramspoth, Marta Castiñeira Reis, Syuzanna R. Harutyunyan

Institutions: University of Groningen, Universidade de Santiago de Compostela, Centro Singular de Investigación en Química Biológica y Materiales Moleculares

Language: English

Topic: Synthesis and Catalytic Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,250