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In Vivo Study to Evaluate the Hepatoprotective Activity of Rohitakadi Vati Against Alcohol Induced Subacute Hepatotoxicity in Rats

Year: 2024

Type: article

Abstract: This study evaluated the hepatoprotective activity of Rohitakadi Vati, an Ayurvedic formulation, against alcohol-induced subacute hepatotoxicity in Wistar rats. A total of 24 rats were divided into four groups: control, disease control (alcohol), standard control (alcohol + Silymarin), and test (alcohol + Rohitakadi Vati). Over a 28-day period, parameters such as body weight, clinical signs, organ weights, biochemical markers, and histopathological changes were assessed. Results showed that Rohitakadi Vati signicantly reduced alcohol-induced liver damage, as evidenced by improved biochemical parameters and reduced histopathological alterations compared to the disease control group. The study concludes that Rohitakadi Vati exhibits signicant hepatoprotective effects comparable to Silymarin, supporting its potential use in managing alcohol-induced liver damage.

Source: GLOBAL JOURNAL FOR RESEARCH ANALYSIS

DOI: 10.36106/gjra/5306327

Authors: Ketan Kurtkoti, Amol Sabale

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404491816

FWCI:

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