Year: 2024
Type: article
Study design: Observational Study
Abstract: We aimed to explore the age-dependent epigenetic variability on the X-chromosome with consideration of X-chromosome inactivation by applying a sex-stratified regression analysis to DNA methylation array data on X-linked CpGs in aging identical twins. We found 13 X-linked CpGs showing age-related significant increase in variability in males (FDR < 0.05) but none in females. In females, we found a significantly higher proportion of CpGs showing increased variability with age among nominally significant (p < 0.05) CpGs under inactivation, but not among CpGs escaping inactivation. Survival analysis showed a slight trend of correlation by directional change in the variable CpGs with mortality in males. Compared with females, the male X-chromosome can be more vulnerable to epigenetic instability during aging.
Source: Epigenomes
Institution: University of Southern Denmark
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,705
Awards: G1218740425, G2476663878, G2606182891, G2810727212, G2934107414, Oldest-old Mortality - Demographic Models and Analysis, G3252911387, G3775192334, G4067196137, G4322971107, G4865497601, Demography of Sex Differences in Health and Survival, G5702163051, Integrated research on DEvelopmental determinants of Aging and Longevity, G7128677839, G7203018943, G7973772284
OpenAlex ID: W4404494705