Isorhamnetin ameliorates dopaminergic neuronal damage via targeting FOSL1 to activate AKT/mTOR in 6-OHDA-induced SH-SY5Y cells
Year: 2024
Type: article
Abstract: Isorhamnetin (Iso) ameliorated neuronal activity damage, senescence, apoptosis, and oxidative stress injury in 6-hydroxydopamine (6-OHDA)-induced SH-SY5Y cells. Iso activated AKT/mTOR signaling pathway via inhibiting Fos-like antigen (FOSL1) in 6-OHDA-induced SH-SY5Y cells. Overexpression of FOSL1 attenuated the protective effect of Iso against 6-OHDA-induced neuronal damage in SH-SY5Y cells.
Source: Journal of Neurophysiology
Authors: Shaochen Qin, Xiaobo Wan, Shanshan Kong, Kunmei Xu, Jungong Jin, Shiming He, Mingsheng Chen
Institution: Shanxi University of Traditional Chinese Medicine
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Award: G7284727057
OpenAlex ID: W4404497132