Work

Pd-Catalyzed Aromatic Dual C-H Acylations and Intramolecular Cyclization: Access to Quinoline-Substituted Hydroxyl Isoindolones

Year: 2024

Type: article

Abstract: A palladium-catalyzed aromatic dual C-H acylations followed with intramolecular cyclizations have been developed by the assistance of bidentate N-(quinolin-8-yl)benzamide. This tandem process involves the formation of three new chemical bonds, providing access to novel quinoline-substituted hydroxyl isoindolones skeleton under simple reaction conditions. The deuterium-labeled competition reaction has revealed that C-H bond cleavage is the turnover limiting step.

Source: Molecules

DOI: 10.3390/molecules29225397

Authors: Hongke Xu, Yuchen Yang, Yuchen Yang, Fei Li, Yuzhu Yang, Yuzhu Yang

Institution: Guiyang Medical University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,069

Funder: West Light Foundation of the Chinese Academy of Sciences