Neighborhood physical activity facilities predict risk of incident mixed and vascular dementia: The Cardiovascular Health Cognition Study
Year: 2024
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Neighborhood environments may promote neurocognitive health in part by providing amenities that encourage physical activity. We examined associations between quantity of walkable facilities, including specifically physical activity facilities (e.g., gyms, recreation centers), with risk of incident dementia. METHODS: Participants included 2923 adults ≥ 65 years old from the Cardiovascular Health Cognition Study (1992-1999), with clinically adjudicated dementia classified over a median 6.0 years of follow-up. Walkable facilities were measured within 1 km (Euclidean) of home. Self-reported baseline physical activity was considered a moderator. RESULTS: In adjusted Cox models, participants with ≥ 2 (vs. 0) physical activity facilities had reduced risk of mixed/vascular dementia, but not Alzheimer's disease, particularly after excluding individuals in the bottom 20th percentile of physical activity (hazard ratio = 0.56, 95% confidence interval: 0.35-0.89). DISCUSSION: Neighborhood amenities that encourage physical activity may mitigate dementia risk via improved vascular health, especially for individuals with sufficient baseline mobility to use these resources. HIGHLIGHTS: We examined associations between nearby walkable facilities and incident dementia. Facilities within 1 km were counted via the National Establishment Time Series Database. More physical activity facilities predicted lower risk of mixed/vascular dementia. No associations were found between walkable facilities and incident Alzheimer's disease.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.14387
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
Funders: Pennsylvania Department of Health, Johns Hopkins University, University of Pittsburgh, Drexel University, National Institutes of Health, Johns Hopkins Bloomberg School of Public Health, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke
Awards: G1023702118, G1097528416, G1220223050, G125972088, G1261314546, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G1401438683, G1438302022, CORONARY HEART DISEASE AND STROKE, G1696540499, G1726490033, G1939093317, G2194386449, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G2391884931, G247538147, G2518747743, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G270907595, G2800149121, G3045517347, G3085334296, G3137375862, G3220743633, G322252321, G3256118428, G34347772, G3494281971, Communities Designed to Support Cardiovascular Health for Older Adults, CHS research resources for the cardiovascular health of older adults, G369899356, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, G4219624527, G422026355, G423252844, G4365909528, G4415104340, G4622379297, G4942589162, G5050292188, G5145575165, G5148796768, G5439707361, G544148272, G5479317095, G5490141068, Neighborhoods, Cognitive Aging and Modifiable Risk Factors, G581887176, CHS Events Follow-up Study, G6226795708, G640327682, G6551505877, CHS-Transition Phase, G7176672723, G7217924807, G764651519, G766700449, G766843672, G806768229, G8068269535, G8518686724, G8681300088, Identifying alcohol-related and built environment factors that can be modified to prevent pedestrian road traffic death, G8892155751, Pittsburgh Older Americans Independence Center, Epidemiology and Biostatistics of Aging, G905887895
OpenAlex ID: W4404502340