Work

l-Tyrosine and l-DOPA: Promising scaffolds for the synthesis of biologically active compounds

Year: 2024

Type: article

Abstract: This review reports the synthetic strategies as well as the physicochemical and biological properties of l -tyrosine and 3,4-dihydroxyphenyl- l -alanine ( l -DOPA) esters, amides, and imine derivatives including dopamines and tyrosol derivatives from 2010 to 2024. The variations in head group and hydrophilic chain were found to influence the physicochemical properties such as critical micelle concentration (CMC), lipophilicity, and surface tension. The biological properties of the previously reported l -tyrosine and l -DOPA derivatives such as radical scavenging, antibacterial, antiproliferative, and anti-Parkinson activities are also reported.

Source: Comptes Rendus Chimie

DOI: 10.5802/crchim.342

Authors: Euphrem Ndayiragije, Prakashanand Caumul, Nausheen Joondan, Minu Gupta Bhowon, Sabina Jhaumeer Laulloo

Institutions: Université du Burundi, University of Mauritius

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: University of Mauritius

OpenAlex ID: W4404505280