Epidemiological insights into severe hepatitis in pediatric inpatients
Year: 2024
Type: article
Study design: Observational Study
Abstract: There is limited statistical data on severe hepatitis among hospitalized children in China at a national level. This nationwide study analyzed data from 34,410 children hospitalized for severe hepatitis in mainland China from 2016 to 2022. The overall in-hospital mortality rate was 6.1%. Viral hepatitis accounted for 14.9% of cases, with hepatitis B being the most prevalent. Indeterminate etiology, present in 79.0% of cases, was an independent risk factor for mortality. Findings emphasize the need for enhanced diagnostic methods and targeted interventions for children with severe hepatitis of unknown cause and suggest focused hepatitis B monitoring in older children to improve outcomes. Establishing a dedicated surveillance system is crucial for improving the prognosis of children at high risk for in-hospital mortality due to severe hepatitis.
Source: iScience
Authors: Fuping Guo, Xudong Ma, Qijun Shan, Yuelun Zhang, Sifa Gao, Jieqin Chen, Yujie Chen, Dawei Liu, Taisheng Li, Feng Zhang, Xiang Zhou
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,150
Funders: Ministry of Science and Technology of the People's Republic of China, Chinese Academy of Meteorological Sciences, Chinese Academy of Medical Sciences, Beijing Municipal Natural Science Foundation, National Key Research and Development Program of China, Chinese Academy of Medical Sciences Initiative for Innovative Medicine
OpenAlex ID: W4404506050