Year: 2024
Type: article
Study design: Case Report
Abstract: Serotonin syndrome (SS) is a potentially life-threatening condition caused by excessive serotonergic activity, often due to drug interactions. It classically manifests with autonomic and neuromuscular hyperactivity and by mental status changes that might include restlessness, delirium, and agitation. We present a case of a 76-year-old patient with Parkinson's disease with SS triggered by interaction between rasagiline and buspirone. He presented with altered mental status, hyperreflexia, and muscle rigidity. Due to the severity of symptoms, he was early admitted to the ICU, and his clinical condition improved after discontinuation of serotonergic agents and supportive care. In SS, a high index of suspicion is fundamental, so early treatment is implemented.
Source: Cureus
DOI: 10.7759/cureus.73963
Authors: José Diogo Martins, Rita Morais Passos, Nuno Pardal, Ana Catarina Carvoeiro, Fernando Correia
Institutions: Unidade Local de Saúde do Alto Minho, University of Minho
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404508341