Research Progress on CRISPR/Cas9-Mediated Gene Editing Combined with CAR-T Tumor Immunotherapy
Year: 2024
Type: article
Abstract: CAR-T cell therapy is a highly promising cancer treatment; however, its application and efficacy are limited by various factors. This paper explores the challenges faced by CAR-T cell therapy, such as antigen escape, treatment side effects, the immunosuppressive microenvironment of solid tumors, and low efficiency of cell migration and infiltration. To overcome these bottlenecks, CRISPR/Cas9 technology can be utilized to enhance CAR-T cells through gene editing, improving their anti-tumor effects. The paper details methods and applications of CRISPR/Cas9 technology in improving CAR-T therapy. Finally, the paper summarizes the current bottlenecks in the field and provides prospects for future development.
Source: Theoretical and Natural Science
Authors: Wenxuan Hu, Xinhui Jiang
Institution: Shanghai Normal University
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4404509330