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t (1;12) (p31; q13) cytogenetic abnormality in a patient of idiopathic hypereosinophilic syndrome: A case report

Year: 2024

Type: article

Abstract: Hypereosinophic syndrome (HES) is a heterogenous group of disorders comprising various etiology. Idiopathic HES is diagnosis of exclusion after morphological, radiological and molecular investigations. Cytogenetic analysis remains an important diagnostic test available in HES. The patient reported here presented with hyper eosinophilia with cardiac, gastrointestinal and pulmonary organ involvement. Chromosomal abnormality of t (1;12) (p31; q13) was found in conventional karyotyping (unstimulated culture, GTG banding) on bone marrow sample. Patient improved after short course of corticosteroid and imatinib mesylate a tyrosine kinase inhibitor (TKI).

Source: Journal of Hematology and Allied Sciences

DOI: 10.25259/jhas_30_2024

Authors: Arjun Kachhwaha, Paras Satadeve, Adamya Gupta, Uttam Kumar Nath

Institution: All India Institute of Medical Sciences Rishikesh

Language: English

Topic: Eosinophilic Disorders and Syndromes

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4404510925

FWCI:

Cites: 10

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Related to: 10