Work

Transdermal delivery of PeptiCRAd cancer vaccine using microneedle patches

Year: 2024

Type: article

Abstract: leading to complete tumor rejection when mice were pre-vaccinated. A rise in the cDC1 population in the lymph nodes of the MN treated mice led to an increase in the effector memory T cells in the body. Thus, the results of this study demonstrate that the combination of MN technology with PeptiCRAd may provide a safer, more tolerable, and efficient approach to cancer immunotherapy, potentially translatable to other therapeutic applications.

Source: Bioactive Materials

DOI: 10.1016/j.bioactmat.2024.11.006

Authors: Carmine D'Amico, Manlio Fusciello, Firas Hamdan, Federica D'Alessio, Paolo Bottega, Milda Saklauskaite, Salvatore Russo, Justin Cerioni, Khalil Elbadri, Marianna Kemell, Jouni Hirvonen, Vincenzo Cerullo, Hélder A. Santos

Institutions: University of Helsinki, HiLIFE – Elämäntieteiden Instituutti, University of Naples Federico II, University Medical Center Groningen, University of Groningen

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,200

Funders: Academy of Finland, Suomen Kulttuurirahasto, Jane ja Aatos Erkon Säätiö, Magnus Ehrnroothin Säätiö, Universitair Medisch Centrum Groningen, Syöpäjärjestöt, Syöpäsäätiö, Horizon 2020 Framework Programme, Helsinki Institute of Life Science, Helsingin Yliopisto, European Research Council, H2020 European Research Council

Awards: G1913243297, G3292757620, G3470850422, G6224935366, Robotic Magnetic Needle Characterization of Single Nanoparticle Uptake in Cells, Personalized oncolytic vaccines for cancer immunotherapy

OpenAlex ID: W4404514447

FWCI: 2.039

Cites: 58

Cited by: 14

Related to: 10