Work

Development of a water-soluble ouroboros-like calix[6]arene-trisimidazole-based ligand for enhanced binding of zinc

Year: 2024

Type: article

Abstract: cation in water, within a pH window centered around 7, through the three imidazole units and one self-included amino leg occupying the coordination site within the macrocycle cavity. The coordination process benefits from a favourable entropic effect, conferring greater thermodynamic stability to the resulting ouroboros-like complex compared to the one stabilized by an exogenous amine. Additionally, the intramolecular coordination ensures a supramolecular protection, which can be exploited for the site-selective functionalization of two out of the three amino groups. These findings demonstrate that the use of macrocyclic ligands capable of forming ouroboros-like molecular complexes represents a valuable strategy for stabilizing metal ions in water.

Source: Dalton Transactions

DOI: 10.1039/d4dt03158j

Authors: Romain Carpentier, Roy Lavendomme, Benoit Colasson, Kristin Bartik, Ivan Jabin

Institutions: Université Libre de Bruxelles, Centre National de la Recherche Scientifique, Université Paris Cité, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Clean water and sanitation

Open Access status: green

Funders: Fonds De La Recherche Scientifique - FNRS, Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture