Work

Crosstalk between cancer-associated fibroblasts (CAF) and tumour cells in head and neck cancer - Unraveling the complex pathway and CAF-targeted therapy

Year: 2024

Type: article

Abstract: • Cancer-associated fibroblasts (CAFs), are critical determinant of HNSCC disease progression and therapeutic outcome. • Relevant 3D in vitro cancer models present a cost-effective platform for preclinical testing. • CAFs and tumour cell interaction mediate a pro-tumoral effect on cancer cells, resulting in faster proliferation, increased stemness, EMT, and therapeutic resistance. • CAF targeted therapy improves the efficiency of currently available cancer treatment regimens that target resistance-related molecules.

Source: Oral Oncology Reports

DOI: 10.1016/j.oor.2024.100690

Authors: J. Nandhini, E. Karthikeyan

Institution: Saveetha University

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100