Generation of a human induced pluripotent stem cell line from a female patient carrying LZTR1 gene mutation
Year: 2024
Type: article
Abstract: The leucine zipper-like transcriptional regulator 1 (LZTR1) gene has been reported to be associated with many kinds of human diseases, including cardiac disease, Noonan syndrome, and schwannomatosis. In this study, peripheral blood mononuclear cells (PBMCs) derived from patient diagnosed with dilated cardiomyopathy (DCM) was successfully reprogrammed into the human induced pluripotent stem cells (iPSCs) line, harboring a distinct heterozygous mutation in the LZTR1 gene. The established patient-derived iPSCs expressed endogenous pluripotent markers, demonstrated the potential to differentiate into three germ layers (endoderm, mesoderm, and ectoderm), and exhibited a normal karyotype.
Source: Stem Cell Research
Authors: Jinghua Ruan, Mengqing Wu, Jiakai Xiang, Xianrui Hui, Lijun Yang, Ru Lin, Weize Xu, Qiang Shu
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,320
OpenAlex ID: W4404517021