Work

Combined lung and liver transplant for cirrhosis, idiopathic pulmonary fibrosis, and hemophilia A: Case report

Year: 2024

Type: article

Abstract: • First documented case of combined liver and lung transplant (CLLT) in a hemophilia A patient. • CLLT may be feasible while dealing with coagulopathy from hemophilia and liver disease. • An individualized, case-by-case approach is crucial in such a complex scenario. • FVIII target levels were 60 % on ECMO and 100–120 % during and after transplantation. • Hemophilia a phenotype was cured after the liver transplantation. Combined lung and liver transplantation (CLLT) is a rare intervention for end-stage lung and liver diseases. It poses a challenge for patients with increased bleeding risk due to Hemophilia A and liver coagulopathy. We present the first documented case of CLLT in an elderly male with Hemophilia A, HCV-associated cirrhosis, and Idiopathic Pulmonary Fibrosis (IPF). Despite the patient exhibiting stable liver function and hemophilia, his lung condition rapidly deteriorated, prompting the listing for transplant. The patient underwent a successful CLLT with perioperative management coordinated by the multidisciplinary team to address the unique challenges of Hemophilia A, resulting in intra-operative correction of coagulopathy. The patient exhibited a favorable recovery, with no requirement for Factor FVIII replacement therapy postoperatively. This case demonstrates that CLLT can address three diseases with distinct pathophysiologies: end-stage lung and liver disease, and correct the hemophilia A phenotype. Our report contributes to the limited literature on the suitability of CLLT in patients with hemophilia A.

Source: Transplantation Reports

DOI: 10.1016/j.tpr.2024.100163