Work

Impaired antiviral immunity in frequent exacerbators of chronic obstructive pulmonary disease

Year: 2024

Type: article

Abstract: COPD exacerbations are commonly triggered by viral infections. Some patients with COPD have frequent exacerbations leading to rapid lung function decline and increased mortality. In this study, antiviral responses (interferons) from bronchial epithelial cells and alveolar macrophages were reduced in patients with COPD compared with healthy participants and further reduced in patients with COPD with frequent exacerbations. Impaired antiviral immunity may lead to frequent COPD exacerbations. Targeted vaccinations and antiviral therapy may reduce exacerbations in COPD.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00118.2024

Authors: Lydia J. Finney, Peter Fenwick, Samuel V. Kemp, Aran Singanayagam, Michael R. Edwards, Kylie B. R. Belchamber, Tatiana Kebadze, Eteri Regis, Gavin D. Donaldson, Patrick Mallia, Louise E. Donnelly, Sebastian L. Johnston, Jadwiga A. Wedzicha

Institutions: Imperial College London, Royal Brompton & Harefield NHS Foundation Trust, Harefield Hospital, Royal Brompton Hospital

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4404526675

FWCI: 2.029

Cites: 45

Cited by: 8

Related to: 10