Work

Trifluoromethylative and Pentafluoroethylative Heterofunctionalization (C–O, C–S, and C–N) of Alkenes Using Visible Light Photocatalysis

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide A mild and general method for photoredox-catalyzed trifluoromethylative and pentafluoroethylative heterofunctionalization of alkenes is proposed. In this reaction, the Togni reagent serves as a CF 3 - or CF 2 CF 3 -radical source for the regioselective formation of the C–CF 3 and C–CF 2 CF 3 bonds from alkenes, and additional nucleophiles (O, S, N) provide C–O, C–S, and C–N bonds, respectively. These reactions provide a common gateway to access the fluoroalkylative heterofunctionalization of alkenes.

Source: ACS Omega

DOI: 10.1021/acsomega.4c06017

Authors: Ye Rin Choi, Seongeun Kang, Junyeon Hwang, Hongchan An, Ki Bum Hong

Institutions: Daegu-Gyeongbuk Medical Innovation Foundation, CHA University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

Funders: Korea Institute for Advancement of Technology, CHA University