Work

Optimized protocol for culturing menstrual blood-derived MSCs for combination with oncolytic adenoviruses in cancer treatment

Year: 2024

Type: article

Abstract: studies using a lung adenocarcinoma mouse model confirmed that hypoxia-conditioned MenSCs had superior tumor-homing abilities. The study also demonstrated the feasibility of establishing a master and working cell bank from a single menstrual blood donation. These findings suggest that hypoxia-conditioned MenSCs could be highly effective as OV carriers, potentially leading to better clinical outcomes in cancer treatment by enhancing tumor targeting and therapeutic efficacy.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2024.200907

Authors: Marcel Costa-Garcia, Laura Moya-Borrego, Ramon Alemany Bonastre, Rafael Moreno Olié

Institutions: Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia

Language: English

Topic: Mesenchymal stem cell research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900