Work

Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing

Year: 2024

Type: article

Abstract: The medicine field continues to encounter obstacles in understanding the etiology of skin inflammation and the process of skin wound repair. Developing sustainable and effective three-dimensional (3D) skin models for investigating inflammatory skin biology remains a challenge. By incorporating halloysite nanotubes (HNT) into a composite collagen/alginate/hyaluronic acid hydrogel, we created a novel 3D skin model and introduced keratinocytes and fibroblast cells into it. We demonstrate that the modified 3D skin model is capable of enhancing the differentiation and adhesion behaviors of keratinocytes and fibroblast cells in vitro and promoting wound healing in vivo . These characteristics highlight the potential of this approach for the study of skin inflammation, wound healing, regeneration, aging, and beyond. • HNT-based hydrogels optimize skin remodeling by enhancing cell proliferation, differentiation, and matrix interactions. • HNT-based hydrogels, sensitive to inflammation, are ideal for advancing 3D skin models. • HNT-based hydrogels promote re-epithelialization and skin regeneration, highlighting their role in skin barrier restoration.

Source: Bioactive Materials

DOI: 10.1016/j.bioactmat.2024.11.013