Work

Tough, durable and strongly bonded self-healing cartilage-mimicking noncovalently assembled hydrogel nanostructures: the interplay between experiment and theory

Year: 2024

Type: article

Abstract: ) was obtained for trimer hydrogels. Moreover, the supramolecular cross-linked assembly of PAM-Ag-BN perfectly exhibited bioactivities, including bone formation ability, self-healing performance, restricted cytotoxicity, and anti-microbial activity. The synergistic effect of nano- and micron-sized particles in PAM-Ag-BN ensued in strong interfacial interlocking through the formation of hydrogen bonding between Ag, BNOH and PAM. Therefore, the fabricated tough hydrogel composite can be a leading biomaterial for soft tissue (articular cartilage) regeneration. The present research opens new directions for developing smart self-healing nanocomposites, which are extensively used in cartilage tissue engineering.

Source: Nanoscale

DOI: 10.1039/d4nr03322a

Authors: Shikha Awasthi, Sarvesh Kumar Pandey, Hulikere Jagdish Shwetha, Nehal, S. Selvaraj

Institutions: Manipal University Jaipur, Maulana Azad National Institute of Technology, Indian Institute of Science Bangalore, Saveetha University

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Indian Institute of Science, Maulana Azad National Institute of Technology, Indian Institute of Technology Kanpur, Department of Science and Technology, Ministry of Science and Technology, India

OpenAlex ID: W4404533053

FWCI: 1.483

Cites: 67

Cited by: 14

Related to: 10