Childhood exposure to non-persistent endocrine disruptors, glucocorticosteroids, and attentional function: A cross-sectional study based on the parametric g-formula
Year: 2024
Type: article
Study design: Observational Study
Abstract: Evidence suggests that endocrine disrupting chemicals (EDCs) may perturb the hypothalamic-pituitary-adrenocortical (HPA) axis, which has a major role in brain development. We aimed to evaluate the effects of childhood exposure to organophosphate pesticides, phenols, and phthalate metabolites, on urinary glucocorticosteroids and inattention in childhood. We used data from the Human Early-Life Exposome (HELIX) cohort (2013–2016) and the parametric g-formula to estimate associations between EDCs, glucocorticosteroids, and hit reaction time standard error (HRT-SE), a measure of inattention, and tested for possible effect modification by sex. We observed a positive marginal contrast (MC) for exposure increases from the 10th to the 90th percentile for methyl-paraben (MC: 0.042 and 95 % confidence interval (CI): (0.013, 0.071)), and the phthalate metabolites oxo-MiNP (MC: 0.023 and 95 % CI: (0.003, 0.044)), oh-MiNP (MC: 0.039 and 95 % CI: (0.001, 0.076)), and MEHP (MC: 0.036 and 95 % CI: (0.008, 0.063)), on HRT-SE, indicating lower attention. Several EDCs were also associated with a positive MC for cortisone, cortisol, and corticosterone production. Increased levels of the glucocorticosteroids were not associated with HRT-SE, although we found a possible effect modification by sex. Our results suggest that multiple EDCs might interfere with inattention and with the homeostasis of the HPA axis. • Endocrine disruptors may perturb the hypothalamic-pituitary-adrenal axis. • We evaluated the effects of childhood exposure to multiple endocrine disruptors. • Phenols and phthalate metabolites were associated with lower attention. • Multiple endocrine disruptors were associated with higher levels of glucocorticoids. • Glucocorticoids were associated with lower attention in a sex-specific manner.
Source: Environmental Research
Institutions: Universitat Pompeu Fabra, Instituto de Salud Carlos III, Barcelona Institute for Global Health, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, MRC Centre for Environment and Health, Imperial College London, University of Southern California, Vytautas Magnus University, Erasmus MC, Université Paris Cité, Université Sorbonne Paris Nord, Norwegian Institute of Public Health, Bradford Teaching Hospitals NHS Foundation Trust, Bradford Institute for Health Research, Centre National de la Recherche Scientifique, Inserm, Institut pour l'avancée des biosciences, Université Grenoble Alpes, Hospital del Mar Research Institute
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,590
Funders: UK Research and Innovation, Centres de Recerca de Catalunya, National Institute for Health and Care Research, British Heart Foundation, Department of Health and Social Care, European Commission, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Generalitat de Catalunya, Fondation pour la Recherche Médicale, Helse- og Omsorgsdepartementet, Université Paris-Sud, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, Mutuelle Générale de l'Education Nationale, Institut pour la Recherche en Santé Publique, Medical Research Council, Economic and Social Research Council, Instituto de Salud Carlos III, Agencia Estatal de Investigación, National Institute of Environmental Health Sciences, FP7 Health, CHIST-ERA
Awards: G1077156815, G1175115578, G1341303, G1583036818, G1631188251, G1779174361, ENVIRONMENTAL HEALTH RISKS IN EUROPEAN BIRTH COHORTS, G2064873908, G210041235, G2262748287, G2325242462, G244766491, G2473961061, G2493824435, G2601397997, G2672435700, G2745558375, G2819494518, G3005324705, G300979063, G31757887, G3207356259, Environmental Chemical Exposures and Longitudinal Changes of Glucose Metabolism, Insulin Sensitivity and B Cell Function in Youth, G3249297036, G34346518, G3480869486, G3681454997, Exposure to Endocrine Disruptors during early life and child Neurodevelopment: the role of the hypothalamic–pituitary–adrenal axis, G393177772, G4042783231, G4062506641, G425668148, G434337789, Effects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicals, European Study of Cohorts for Air Pollution Effects, Advancing Tools for Human Early Lifecourse Exposome Research and Translation, G5080475149, G5195188938, G5640424767, G5702163051, G630635040, An integrative strategy of testing systems for identification of EDs related to metabolic disorders, The Human Early-Life Exposome – novel tools for integrating early-life environmental exposures and child health across Europe, G6656126374, G6844935297, G6882353668, G69051668, G7084143925, G7689853932, G788349370, Metabolomic and omic assessment of biological ageing across the life-course (METAGE), G8440511448, G8538723892, G8637226926, G8696694383
OpenAlex ID: W4404533448