Work

Photon-Scanning Approach to Control Spiral Wave Dynamics in the Heart

Year: 2024

Type: article

Abstract: Self-organizing spiral electrical waves are produced in the heart during fatal cardiac arrhythmias. Controlling these waves is therefore an essential step in managing the disease. Here we present an effective method for controlling cardiac spiral waves using optogenetics. The method involves using photons to actively scan the surface of the heart for phase singularities. Once detected, these phase singularities are redirected to an inexcitable wall to be eliminated. Thus, spiral waves can be controlled in a double-blind fashion. We present two theoretical mechanisms with ex vivo validation.

Source: Physical Review Letters

DOI: 10.1103/physrevlett.133.218401

Authors: Laura Diaz-Maue, Vladimir S. Zykov, Rupamanjari Majumder

Institutions: Max Planck Institute for Dynamics and Self-Organization, Institut du Thorax, Nantes Université

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Agence Nationale de la Recherche, Max-Planck-Gesellschaft