Work

Harnessing Naturally Occurring Bistable Switches for Their Application in Synthetic Biology

Year: 2024

Type: article

Abstract: Bistability is a fundamental phenomenon in nature. In biochemical systems, it creates digital, switch-like outputs from the constituent chemical concentrations and activities, and it is often associated with hysteresis in such systems. Here, we first introduce the regulation of bistable switches at different levels in natural life systems, then explain the current pioneering applications of bistable switches in synthetic biology, and finally introduce some design and tuning methodologies and principles that may be helpful for the future application of bistable switches in synthetic biology.

Source: SynBio

DOI: 10.3390/synbio2040023

Authors: Ma Huan, Guanyu Wang

Institutions: Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,137

Funders: National Natural Science Foundation of China, National Key Research and Development Program of China, Shenzhen Peacock Plan