The individual and combined effects of polycyclic aromatic hydrocarbons on asthma among US children: evidence from the NHANES study
Year: 2024
Type: article
Abstract: Polycyclic Aromatic Hydrocarbons (PAHs) exposure has been linked to asthma, but their individual and combined effects in children remain unclear. Using data from the 2003-2012 National Health and Nutrition Examination Survey (NHANES), we investigated the associations between PAHs and asthma through logistic regression, Weighted Quantile Sum (WQS) regression, Quantile g Computation (qg computation), and Bayesian Kernel Machine Regression (BKMR). Subgroup analyses revealed a significant impact of PAHs on asthma, particularly in males. The WQS model showed a marginally significant combined effect of 9 PAHs on asthma (Odds Ratio = 1.37, 95% Confidence Interval: 1.06-1.75). BKMR also indicated a positive association between combined PAH exposure and asthma. 2-Hydroxyfluorene and 1-Hydroxypyrene were identified as the most significant contributors. These findings suggest that mixed PAH exposure is associated with asthma risk in children.
Authors: Yang Yang, Yufang Hu, Jiaqi Cui, Xiaodan Li, Xinxin Zhang, Qi Sun, Qi Zhang
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
Funder: Ministry of Education, India
OpenAlex ID: W4404534631