Work

R(+) propranolol decreases lipid accumulation in haemangioma-derived stem cells

Year: 2024

Type: article

Abstract: Infantile haemangioma (IH), often treated with propranolol, is a benign vascular tumour that undergoes a spontaneous involution to a fibrofatty residuum. We investigated how R(+) propranolol, the nonbeta blocker enantiomer of racaemic propranolol, affects lipid accumulation and adipogenesis in IH. This was motivated by our previous work showing that R(+) propranolol can block blood vessel formation in a preclinical model of IH. Our findings suggest a novel regulatory role for R(+) propranolol in modulating lipid accumulation in haemangioma stem cells. This highlights a novel role for R(+) propranolol in the involuting phase of IH and offers a strategy to reduce fibrofatty residua in IH.

Source: British Journal of Dermatology

DOI: 10.1093/bjd/ljae452

Authors: Jerry Wei Heng Tan, Jill Wylie-Sears, Caroline T Seebauer, John B Mulliken, Mathias Francois, Annegret Holm, Joyce Bischoff

Institutions: Boston Children's Hospital, Harvard University, Nanyang Technological University, University Hospital Regensburg, Luzerner Kantonsspital, The University of Sydney, Centenary Institute

Language: English

Topic: Vascular Malformations and Hemangiomas

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Boston Children's Hospital, Nanyang Technological University, Deutsche Forschungsgemeinschaft, University of Sydney, National Institutes of Health, Directorate for Biological Sciences, Medical Research Council, National Health and Medical Research Council, National Heart, Lung, and Blood Institute

Awards: G3137745492, Mechanismen der vaskulären Wachstumskontrolle bei infantilen Hämangiomen, A single molecule resolution approach to decipher the transcriptional regulation of endothelial cell fate, G9000125242

OpenAlex ID: W4404535455

FWCI: 1.551

Cites: 8

Cited by: 4

Related to: 10