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Refractory Tophaceous Gout With Psoriatic Arthritis: A Case Report

Year: 2024

Type: article

Abstract: Although gout is a common intermittent crystalline arthropathy, tophaceous gout is a rare condition. Flares of this disease are usually treated with anti-inflammatory drugs followed by control of serum uric acid levels. We present a refractory, severe, tophaceous gout overlapping with psoriatic arthritis, presenting with a hyper-inflamed phenotype resistant to conventional anti-inflammatory and hypouricemic agents. Control of the disease was only achieved after the introduction of IL-1-blocking therapy. This case highlights the need to control inflammation as the first step in gout treatment and underscores the increasing need for personalized therapies in more complex patients.

Source: Cureus

DOI: 10.7759/cureus.74079

Authors: Rui Coelho, Isabel Fonseca Silva, Sara Xavier Pires, Tomás Fonseca

Institution: Unidade Local de Saúde de Santo António EPE

Language: English

Topic: Gout, Hyperuricemia, Uric Acid

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404538426