Year: 2024
Type: article
Abstract: Hearing impairment has been widely concerned as a social health problem with high incidence. About 60% of cases of sensorineural hearing loss are caused by mutations in genetic material. The clinical treatment of hereditary deafness mainly relies on cochlear implants and hearing AIDS, and the development of more effective and comprehensive biological treatment methods is imminent. Repairing the damaged genes is an effective way to fundamentally treat hereditary deafness. Several studies have shown that the replacement or repair of mutant genes in inherited deafness mouse models can effectively restore the impaired hearing in mice. At present, gene therapy has successfully restored hearing in patients with hereditary deafness carrying OTOF mutations. There are more than 200 deafness genes including OTOF. As a precision therapy, there are still many problems need to be solved in the application of gene therapy in hereditary deafness. In this paper, the occurrence and development of hereditary deafness are summarized, and then the current research progress of gene therapy applied to the clinical treatment of hereditary deafness is deeply discussed, and the dilemma and challenge of gene therapy for deafness at this stage are put forward.
Source: Scientia Sinica Vitae
Authors: Yinyi ZHOU, Xuehan YANG, Yicheng LU, Xiaohan WANG, Xiangyan CHEN, Jinyi FAN, Xinru ZHANG, Xianmin WU, Liyan ZHANG, Fangzhi TAN, Jieyu QI, Renjie CHAI
Language: English
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4404546249