Recipient‐Donor Sex Constellation in Liver Transplantation for Hepatocellular Carcinoma—An ELTR Study
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Liver transplantation (LT) is a curative treatment option. We investigated survival outcomes based on recipient-donor sex constellation (RDSC) following LT. METHODS: We performed a European Liver Transplant Registry analysis, including patients from 1988 to December 2022. The cohort was split into four RDSC groups: female donor female recipient (FDFR), female donor male recipient (FDMR), male donor female recipient (MDFR) and male donor male recipient (MDMR). Survival analysis, including death with recurrence, was performed. RESULTS: In 7601 LT for HCC with an overall median follow-up of 22.6 months (5.8, 60.7), death was registered in 25.1% and, as primary cause of death, HCC tumour recurrence in 26.0%. There was no statistically significant difference on crude survival estimates among the different RDSC groups (log-rank p = 0.66) with 10-year overall survival (OS) of 54.5% in FDFR, 54.6% in FDMR, 59.1% in MDFR and 56.9% in MDMR. On multivariable analysis, RDSC showed a significant effect on OS (FDFR as reference): MDFR (aHR 0.72, p = 0.023). No significant difference was found for FDMR (aHR 0.98, p = 0.821) and MDMR (aHR 0.90, p= 0.288). Regarding overall registered causes of death, differences between RDSC groups were found in rejection (p = 0.017) and cardiovascular (p = 0.046) associated deaths. CONCLUSIONS: In female recipients undergoing LT for HCC, male donor grafts were associated with a 28% reduction of mortality compared to female donor grafts.
Source: Liver International
DOI: 10.1111/liv.16178
Authors: Christian Tibor Josef Magyar, Noah Free Arteaga, Giacomo Germani, Vincent Hassan Karam, Rene Adam, Renato Romagnoli, Paolo De Simone, Fabien Robin, Daniel Cherqui, Andrea Boscà, Vincenzo Mazzaferro, Yiliam Fundora, Michael Heneghan, Laura Llado, Mickael Lesurtel, Matteo Cescon, Darius Mirza, Andrea Cavelti, Lucienne Christen, Federico Storni, Corina Kim‐Fuchs, Anja Lachenmayer, Guido Beldi, Daniel Candinas, Iuliana‐Pompilia Radu, Birgit Schwacha‐Eipper, Annalisa Berzigotti, Vanessa Banz
Institutions: University of Bern, University Hospital of Bern, University of Padua, Azienda Ospedale - Università Padova, Université Paris-Saclay, Hôpital Paul-Brousse, University of Turin, University of Pisa, Azienda Ospedaliera Universitaria Pisana, Hôpital Pontchaillou, Université Rennes 1, Université de Rennes, Hospital Universitari i Politècnic La Fe, University of Milan, Fondazione IRCCS Istituto Nazionale dei Tumori, Hospital Clínic de Barcelona, King's College Hospital, Bellvitge University Hospital, Université Paris Cité, Hôpital Beaujon, University of Bologna, Queen Elizabeth Hospital Birmingham
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,740
Funder: Astellas Pharma
OpenAlex ID: W4404546393