Work

Asymmetric ‘Clip-Cycle’ synthesis of 3-spiropiperidines

Year: 2024

Type: article

Abstract: -Cbz-protected 1-amino-hex-5-enes with a thioacrylate. This is followed by the 'Cycle' step, in which an intramolecular asymmetric aza-Michael cyclization is promoted by a chiral phosphoric acid catalyst.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d4ob01608d

Authors: Saikiran Ravi, Christopher J. Maddocks, Ian J. S. Fairlamb, William P. Unsworth, Paul A. Clarke

Institution: University of York

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: University of York, Royal Society

OpenAlex ID: W4404547296

FWCI: 0.424

Cites: 38

Cited by: 3

Related to: 10