Targeting SLC7A11 /xCT improves radiofrequency ablation efficacy of HCC by dendritic cells mediated anti‐tumor immune response
Year: 2024
Type: article
Abstract: After RFA treatment in patients with liver cancer, the expression of SLC7A11/xCT and the proportion of DCs in the TME were significantly increased. SLC7A11/xCT is a poor prognostic marker for liver cancer and is mainly expressed in DCs in the TME. Targeting xCT in DCs combined with RFA significantly enhances anti-tumor immunity, suppressing tumor growth and offering a promising strategy for improved therapeutic outcomes in liver cancer.
Source: iMeta
DOI: 10.1002/imt2.248
Authors: Yuzhao Jin, Songhua Cai, Yang Zhou, Dandan Guo, Yuzhen Zeng, Wangting Xu, Yiting Sun, Yueli Shi, Zhiyong Xu, Zaoqu Liu, Peng Luo, Zhao Huang, Bufu Tang
Institutions: Wenzhou Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College, Fudan University, Zhongshan Hospital, Dalian Medical University, First Affiliated Hospital of Dalian Medical University, Sir Run Run Shaw Hospital, Zhejiang University, China Medical University, Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences, Zhujiang Hospital, Southern Medical University, Tongji Hospital, Huazhong University of Science and Technology
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid:
Awards: G2601117933, G6233289138
OpenAlex ID: W4404547541